WebMay 1, 1999 · There are many methods for determination of stability constants of CyD complexes, using techniques such as solubility ( Higuchi and Connors, 1965 ), potentiometry ( Miyaji et al., 1976 ), high-pressure liquid chromatography ( Uekama et al., 1978 ), and kinetic ( Bender and Komiyama, 1978) and spectroscopic ( Cramer et al., 1967, Thakkar et … WebHiguchi et. al, "Phase-Solubility Technique in Studying the Formation of Complex Salts of Triamterene,", 1964. Higuchi and Connors, "Phase-Solubility Techniques,", 1964. Higuchi …
Phase solubility diagrams and their classification according to Higuchi …
WebFeb 27, 2010 · According to Higuchi and Connors there can be five types of phase-solubility relationship (Fig. 1 ): A L -type where there is a linear relationship between substrate (drug) solubility and ligand (cyclodextrin) concentration and which is interpreted as formation of a complex with m :1 stoichiometry; A P -type, which represents positive deviation … WebAug 8, 2024 · The method of Higuchi and Connors proposes that to determine the inclusion constant of a formed complex 1H 4 MGF:1βCD, the phase-solubility diagram, ( [H 4 MGF] = f ( [βCD])) of saturated solutions in mangiferin must show a linear trend and then equation ( 6) relates the slope ( α) and intercept ( G0) of the straight line with the equilibrium … how to shutdown asus laptop with keyboard
(PDF) Phase solubility studies of the inclusion complexes of ...
WebTypes of phase-solubility diagrams according to Higuchi and Connors [11] showing how the total drug solubility changes with increasing CD concentration. A-type diagrams are … WebMar 22, 2024 · We also introduced the Higuchi and Connors method to analyze inclusion complex formed through solubilization and the pharmaceutical benefits that can be gained using CDs. In addition, the practical applications of CDs in nasal, ophthalmic, pulmonary, and rectal drug delivery are also described. CD applications for drug solubilization WebPersonal papers of Takeru Higuchi, PP 359. University of Kansas. Kenneth Spencer Research Library. Higuchi and Connors, "Spectrophotometric Detection of the End Point in the Karl Fischer Titration of Water,", 1959, Box: 11, Folder: 110. Personal papers of Takeru Higuchi, PP 359. University of Kansas. Kenneth Spencer Research Library. how to shutdown blox fruits priv