Shaomeng wang group umichigan
WebbThe natural product-like compound 1 was identified as a direct inhibitor of the menin–MLL interaction by in silico screening. Structure-based optimization furnished analogue 1a, which showed significantly higher potency than both the lead structure 1 and the reference compound MI-2. WebbWang is also on the board of Ascentage Pharma Group International Co., Ltd., Oncopia Therapeutics, Inc., Rogel Cancer Center: University of Michigan and Ascentage International Ltd. Shao Meng Wang previously held the position of Editor-in-Chief at Journal of Medicinal Chemistry, Professor at the University of Michigan, Assistant Professor at Georgetown …
Shaomeng wang group umichigan
Did you know?
WebbDepartment of Internal Medicine. Division of Hemotology/Oncology. 1500 E. Medical Center Drive. 3110/3120 CCGC. Ann Arbor, MI, 48109-0934. (734) 615-8495 (O) (734) 647-9647 … Webb1 okt. 2024 · Among them, Shaomeng Wang reported two most potent PROTACs which could degrade proteins when the concentration was only at picomolar level, 11 and 12 (Fig. 3) [40, 41]. 11 could lower levels of BRD3 and BRD4 when the concentration was only at 10 pM, while the expression of BRD2 could be reduced when 11 reached 30–100 pM. 11 …
[email protected] didates for further experimental characterization. The basic assumption underlying structure-based drug de-sign is that a good ligand molecule should bind tightly to its target. WebbWang LD, Shaomeng Wang and Sun D. Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling of an Antagonist (SM406/AT-406) of Multiple Inhibitor of …
Webb13 dec. 2024 · Shaomeng Wang and Gunda I. Georg J. Med. Chem.2012,55,1,1-1 Publication Date(Web):December 22, 2011 Full Text PDF Synthesis of biologically active taxol analogs with modified phenylisoserine side chains Gunda I. Georg, Zacharia S. Cheruvallath, Richard H. Himes, Magdalena R. Mejillano, and Charles T. Burke J. Med. … WebbShaomeng Wang Crizotinib is the first anaplastic lymphoma kinase (ALK) inhibitor to have been approved for the treatment of non–small cell lung cancer (NSCLC) harboring an …
Webb11 nov. 2024 · Based on our previous STAT3 SH2 domain inhibitor CJ-887 (compound 1) (Chen et al., 2010a), we have performed extensive optimization, as summarized in Figure 1 A, to obtain potent and cell-permeable STAT3 inhibitors.First, we designed compound 2 by cyclization of the amino group with the phenyl group to form an indole, which binds to … sharif lsuWebb13 dec. 2024 · Professor Shaomeng Wang’s Research Highlights. Shaomeng published his first paper in J. Med. Chem. in 1994,17 which focused on modeling the binding site of … popping rock candyWebbShaomeng Wang is a Chinese-American chemist currently the Warner-Lambert/Parke-Davis Professor in Medicine at University of Michigan [1] and a former Co-Editor-in-Chief at … shari flowers rheumatologist rockaway njWebbWe first designed SI-109 as a potent, small-molecule inhibitor of the STAT3 SH2 domain. Employing ligands for cereblon/Cullin 4A E3 ligase and SI-109, we obtained a series of … popping sensation early pregnancyWebbDr. Shaomeng Wang has b een working on the discovery and development of novel small molecules therapeutics for more than 20 years. One area of research has been focused … popping rods for saltwaterWebb15 maj 2013 · Our study has led to the identification of a set of highly potent MDM2 inhibitors with a stereochemistry that is different from that of our previously reported compounds. The most potent compound (MI-888) binds to MDM2 with a Ki value of 0.44 nM and achieves complete and long-lasting tumor regression in an animal model of … popping severe acne blackhead on mouth videosWebbShaomeng Wang. University of Michigan. Verified email at umich.edu ... Computer automated log P calculations based on an extended group contribution approach. G … popping sensation in throat when swallowing